Left-Handed Ergonomic Mouse – Best Vertical Mouse in 2022

If you have a bad wrist, a left-handed ergonomic mouse can be a real life-saver. That’s because it forces your wrist into an open position that feels much better than a conventional grip. The neutral configuration can help those who suffer from any repetitive motion stress as the natural resting position of your forearm is very relaxed as opposed to the straight-out position of a traditional flat mouse.

“Ergonomic” can sometimes mean expensive, but the good news is there is no need to feel like you’re breaking the bank to get a good mouse for your hand. There are many ergonomic mice at different prices and ranging from $20 and up. You have to know what type of mouse you are ideally looking for to purchase. Some high-end ergonomically designed mice cost upwards of $100, depending on the model.

When it comes to the best left-handed vertical mouse, you need to depend on the available options. There are only a few good ergonomic mice available for left-handed users. So, we have selected the top 5 left-handed mice with ergonomic layout after hours of research and performance comparison. Feel free to buy anyone according to your requirements, as each product fits perfectly for the southpaws.





Logitech MX Vertical Mouse

Evoluent VM4L VerticalMouse

DELUX Wired Ergonomic Vertical Mouse

AURTEC Rechargeable 2.4G

Anker 2.4G Wireless Vertical Ergonomic Mouse

Logitech MX Vertical Mouse

logitech mx vertical mouse

Rating: 4.5 out of 5.
SpecificationsManufacturer: Logitech
Model: MX Vertical Wireless
Sensor: Optical
DPI: 1,000
Connectivity: USB/Wireless
Buttons: 4
Layout: Left Handed
Weight: 8 ounces

The Logitech MX Vertical is a unique mouse for southpaws looking for an ergonomic design. Although the vertical design may take some getting used to, it works very well after getting accustomed to it. The device isn’t exactly travel-friendly, but it’s great if you only need the mouse at your desk and don’t need it from portability. It performs very well and has good software for customization.

The general oval base is a familiar build, but the curved handle coming off of it has a textured shell design while simultaneously providing a comfortable resting spot for your thumb during play. The left side has a more sharp shape, giving you a thumb rest while also leaving room for your middle finger to rest on top of the mouse’s body.

The Logitech MX Vertical Optical Mouse has a DPI of up to 4000. The MX Vertical comes with the same technology as the MX Master 3, released a year later. It is excellent for individuals who are not gamers and are more inclined to use this mouse for work purposes rather than the intended gaming environment. It does slightly hurt when you look at the gaming industry and see that similarly priced mice have more versatile specifications available.

Logitech MX left-handed ergonomic mouse also has long battery life. Logitech claims it should last for about four months without a charge, but we have found that it dropped to 40% battery anywhere from two to three weeks with the backlight off before going into “low” power mode. So that might be an overstatement, but it still lasts for at least six or eight weeks on a full charge as opposed to four months as advertised.

The MX Vertical, like most vertical mice, is best suited for office or multimedia use. It has the incredible build quality and an ergonomic shape that encourage the utmost comfort for those who need to program or work on their computer for long periods. This mouse features excellent wireless connectivity options. It also has several buttons that you can bind with various functions depending on what you need at the moment.

  • Great overall performance
  • Solid build quality
  • Excellent wireless connectivity
  • Good battery life
  • Ease of use with comfortable design
  • Feels heavy
  • It needs some time for getting used to

Evoluent VM4L VerticalMouse 4

Rating: 4.5 out of 5.
SpecificationsManufacturer: Evoluent
Model: VM4L VerticalMouse 4
Sensor: Optical
Connectivity: USB/Wired
Buttons: 6
Layout: Left Handed
Weight: 7.05 ounces

The Evoluent VerticalMouse 4 is the next mouse to come from developer Evoluent. This manufacturer takes a unique approach to their design as they often base it around hand comfort instead of the overall design. The overall design of the mouse makes it unique and one of a kind. Where some manufacturers only rely on ergonomics as a selling point for the product, Evoluent has used a lot more features, including a smooth navigation experience and customizable technology.

The VerticalMouse’s design mimics its name, aligning its buttons in vertical lines that perfectly match the orientation of your fingers when you hold onto it for support. Rather than having to twist your arm at an awkward angle, the ergonomic aids in the VerticalMouse help maintain a relaxed hand posture. You can navigate with ease while also relieving any pressure or tension in the muscles surrounding your forearm and wrist.

The VerticalMouse 4 is plug-and-play; you don’t need to install additional software to get the mouse up and running. However, for those who want to adjust their navigating experience, Evoluent does include a specialized piece of software that can tailor the settings and utilities on your mouse to suit your exact needs. 

The Evoluent VerticalMouse 4 left-handed ergonomic mouse comes with Mouse Manager software which allows you to modify the settings on your mouse button to make it work best for you. The software is compatible with Windows 7 and 10 and Mac OS 10.5 and above. It provides a lot of functionality that’s incredibly intuitive to use – you won’t have a hard time getting the hang of it.

The VerticalMouse 4 is different from your traditional mouse. However, this doesn’t mean you can’t use it as effectively as you would a conventional horizontal mouse. If you have been using conventional horizontal mice all your life, the VerticalMouse 4 will drastically improve the navigating experience and put less strain on your wrist.

Thanks to its patented design, the Evoluent VerticalMouse provides users with maximum comfort and ensures they can use their computers easily for longer periods. Featuring plug-and-play compatibility, this mouse can work with any operating system that supports USB devices.

  • Easy plug and play capabilities
  • Comfortable and ergonomic design
  • It comes with customizable software
  • Good DPI switching
  • Strongly Built
  • Dust attracting plastic
  • The user interface could look finer

DELUX Wired Ergonomic Vertical Mouse

Rating: 4.5 out of 5.
SpecificationsManufacturer: Delux
Model: Ergonomic Vertical Mouse
Sensor: Optical
DPI: 4,000
Connectivity: USB/Wired
Buttons: 6
Layout: Left Handed
Weight: 7.4 ounces

The Delux Ergonomic Vertical mouse offers an ergonomic design at a price point that is more affordable than its competitors but still does what it needs to do to help your stress levels. It offers support for your hand and wrist, with a unique vertical orientation. This left-handed vertical mouse is fantastic for regular office tasks. However, trying it for long game sessions minimizes the tension on your hands even after prolonged usage.

This mouse is one of the most reasonably priced ergonomic gaming and office mice. It has a lot of fantastic qualities. One of our favorite things about this mouse is that you can adjust the DPI settings to make sure it suits your needs. It makes it pretty convenient since we can adapt to 800 DPI when working and then 1600 or 2400 DPI once we start to play games on our computer. With settings ranging from 800-4000 DPI, we won’t miss a shot no matter what.

The RGB chasing lighting enhances the gaming experience by providing soothing lights that match your rig’s colors or change based on how you’re playing. If you’re not a fan of RGB lights but still want an ergonomic mouse that can keep up with your top-notch gaming setup, Delux is perfect for you because it’s easy to use and can be programmed. You can switch between no RGB and lighting modes efficiently.

The support feels comfortable around our wrist and palm area for gaming, which helps us maneuver comfortably while playing games. The improved layout looks pretty good because the pad provides an added layer of protection from friction near the wrist area. Right out of the box, it performs well in our game play testing because the movement of our cursor on-screen appeared natural and sensitive to subtle hand movements.

Overall, Delux Ergonomic mice are the best vertical mouse for gaming and office. It is simple in terms of features and can perform as intended. Moreover, it is compatible with Windows & macOS, making it a versatile choice. It is an affordable left-handed ergonomic mouse because of its ability to increase comfort and performance, making it an excellent choice for gamers and office users.

  • Fit well with full palm grip
  • Attractive and comfortable design
  • RGB lights customization
  • Stable and sharp performance
  • The mouse wheel looks substandard

AURTEC Rechargeable 2.4G Wireless Ergonomic Vertical Mice

Rating: 4.5 out of 5.
SpecificationsManufacturer: AURTEC
Model: AURTEC Rechargeable 2.4G Wireless
Sensor: Optical
DPI: 1,600
Connectivity: USB/Wireless
Buttons: 6
Layout: Left Handed
Weight: 3.10 ounces

When it comes to searching for a wireless left-handed mouse, often customers can end up having to buy countless replacement batteries due to continuous use and lack of time to recharge them. Fortunately, AURTEC has taken care of this issue by creating a unique ergonomic left-handed mouse equipped with a LED indicator for battery life and a USB charging cable. It means there’s no need for constant purchasing and replacing.

The AURTEC features a comfortable left-handed design, with thumb rests explicitly designed to fit the average lefty’s grip. The contour helps seal around your hand comfortably, leaving you with less hand strain after long periods of use. Six buttons give you the power to do serious work quickly and efficiently, whether dragging and dropping files or folders, selecting multiple files at once, copying large amounts of data, or gaming casually. The AURTEC is an all-around great mouse that fits just about any computing need.

This 2.4GHz wireless mouse features a Nano receiver with up to 33ft/10m of operating range, gorgeous colors, futuristic design, ambidextrous operation, easy-access buttons, and three levels of mouse sensitivity up to 1,600 DPI for enhanced tracking. It packs the features that you want for casual gaming and work needs at a budget price.

The AURTEC Wireless Rechargeable Mouse is an excellent choice if you don’t want to worry about ever having to deal with low charging issues. It has both wireless and wired capabilities, which means you can switch between formats as needed, eliminating some of the hassles of having to worry about getting a mouse that works for your specific needs or limitations. You can charge the mouse by simply plugging it into a USB port.

AURTEC’s left-handed ergonomic mouse is much like any other you would use to navigate around your computer – except its stress-free ergonomic vertical design. There are no batteries required; plug in your computer and start using it. AURTEC’s mouse provides both wired and wireless charging that making it a good choice for portability needs.

  • Ergonomic design with a comfortable grip
  • Both USB and Wireless charging options
  • Battery saving sleep and wake function
  • Requires no driver installation
  • Powerful battery
  • No compatibility with Mac OS
  • Simple and boring design

Anker 2.4G Wireless Vertical Ergonomic Mouse

SpecificationsManufacturer: Anker
Model: Anker 2.4G Wireless
Sensor: Optical
DPI: 1,600
Connectivity: Wireless
Buttons: 6
Layout: Left Handed
Weight: 3.36 ounces

The Anker Wireless Vertical Mouse offers a comfortable design to those who experience sprained wrists from being on the computer for long periods. Its vertical design is easy to use and ideal for those who want a mouse that will support their wrist to prevent further injuries. It only comes with three CPI options while having slightly high click latency.

The Anker Vertical Mouse is a little on the tall side compared to other mice. The vertical design has it built like a handshake, which you will hold as your hand meets the desk’s surface at almost a 90-degree angle. The hand almost looks like it’s hovering above the mouse, and there’s a minimal twisting of the wrist as you hold it. This mouse features a plastic matte surface that allows for a less slippery grip.

The Anker left-handed ergonomic mouse uses AA batteries (not included) that will last roughly three months. To activate the mouse, you slide in two AA batteries into empty slots. You then turn it on via a switch located underneath the mouse. A USB receiver can be stored underneath the mouse when not in use and connects with your computer via a 2.4G wireless connection to provide an effective range of around 3 feet.

We like the way that Anker has equipped their Vertical mouse with a physical DPI switch. One-click of the button will decrease or increase sensitivity so you can exactly get what you want. Never have to deal with mouse sensitivity settings from software again. This little feature makes adjusting your cursor speed super easy.

We recommend the Anker wireless vertical mouse for those on a specific budget and that need an ergonomic option. The mouse is comfortable to use during long hours, but its vertical design helps place your wrist in a neutral position. Its six buttons are great for seamless web browsing.

  • The excellent design prevents wrist twisting
  • Comfortable for long hours
  • Budget price
  • Premium build quality
  • Responsive and versatile optical sensor
  • Mouse surface feels slippery
  • Higher click latency

Bottom Line

The best left-handed ergonomic mouse is an excellent choice for preventing the hand and wrist from straining. It provides good support for the mouse grip to keep the hand relaxed and comfortable in the workspace. Also, Have a look at Logitech Left Handed Mouse.

We recommend Logitech MX Vertical Mouse if you need a vertical mouse for ergonomic grip and precise performance. However, if you feel the price is a little higher, AURTEC Rechargeable 2.4G Wireless Ergonomic Vertical Mice is the budget choice that can provide similar performance in fewer bucks.